In the past few years, more than a dozen studies have suggested that beta blockers hold substantial potential for therapeutical interventions in cancer.
Clinical News
The Interplay between Neuropeptide Y, Neuropeptide Y2 Receptors and Pro-Inflammatory Cytokines May Contribute To Atherosclerotic Plaque Instability
- 28 March 2013
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Increasing body of evidence indicates that both inflammation and psychological stress contribute to the development of atherosclerosis.
An Enterovirus Attacking the Thymus, the Safeguard Organ against Autoimmunity, May Play a Key Role in Triggering Type 1 Diabetes
- 14 December 2012
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While an increasing number of studies, mainly epidemiological, indicate that coxsackie viruses (CVs) play a role in the pathogenesis of autoimmune type 1 diabetes (T1D), the mechanisms of action of these viruses remain elusive.
Expression of Neurotensin and Its Receptors in B Cells: Implications for Chronic B Cell Lymphocytic Leukemia
- 14 December 2012
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Neurotensin is a 13-amino acid peptide discovered and isolated in 1973, from extracts of bovine hypothalamus by Robert Carraway and Susan Leeman.
Maternal Stress, Neuropeptide Y – NPY-Y2R System and Programming for the Offspring’s Vulnerability to Obesity and Metabolic Syndrome
- 09 November 2012
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According to CDC more than one-third of U.S. adults (35.7%) are obese.
Psychological Distress Is Dose-Dependently Related to Increased Mortality
- 20 September 2012
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Psychological stress has been linked to the development and progression of several common human diseases including allergy, cancer, cardiovascular and autoimmune disorders (see Clinical Aspects, News and Features and Faces sections, and Evolving Concepts category of this website).
An Autonomic Nervous System Shift Linked to High Occurrence of Infections following Acute Intracerebral Hemorrhage
- 13 July 2012
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Stroke is a major cause of morbidity and the third leading cause of death in the Western world.
New Evidence That Stress-Induced Glucocorticoid Receptor Resistance is Linked to Inflammation and Increased Disease Risk
- 12 April 2012
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The hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary system are the two major peripheral components of the stress system.
New Evidence That Anxiety and Vulnerability to Stress Contribute to the Development of Dementia
- 20 March 2012
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Emerging research implicates a consistent reciprocal relationship between late-life anxiety and cognition, and that severe anxiety may predict future cognitive decline.
Interleukin-6 – a Better Predictor of Future Cardiovascular Events Than C-Reactive Protein?
- 05 March 2012
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One of the paradigm shifts in our understanding about atherosclerosis in the last 10-15 years is the development of the concept that it is potentially caused by a chronic inflammation.
Functional Polymorphism in the 5HTR2C Gene Linked to Enhanced Stress-Induced Cortisol Response
- 03 February 2012
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Enhanced hypothalamic–pituitary–adrenal (HPA) axis and cortisol responses to stress have been linked to high levels of hostility, pathogenesis of the metabolic syndrome and cardiovascular disease incidence.
Signaling Through Neuropeptide Y1 Receptor – a Critical Pathway in Allergic Inflammation
- 23 January 2012
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Neuropeptide Y (NPY) is a 36 amino acid peptide discovered in 1982 by Kazuhiko Tatemoto, Mats Carlquist and Viktor Mutt.
First Experimental Evidence That Stress, Epinephrine and Prostaglandin-E2 Promote Leukemia Progression
- 09 December 2011
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An increasing body of evidence indicates that psychological stress might be linked to the onset, expression or progression of several human malignancies such as tumors of the breast, skin, reproductive system and the gastrointestinal tract.
Tumor Necrosis Factor – a Possible Link Between Age-Related Endocrine Dyscrasia and Alzheimer’s Disease
- 21 October 2011
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Endocrine dyscrasia is an age-related dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis and is associated with dyotic signaling and the induction of neurodegenerative cascades within the brain.
Elevated Plasma IL-10 Levels are a Strong Predictor of Long-Term Adverse Outcomes in Acute Coronary Syndrome
- 04 October 2011
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Interleukin (IL)-10 is an immunoregulatory cytokine with strong anti-inflammatory properties.
Cytokine Profiles in Subjects with Autism Spectrum Disorders
- 13 September 2011
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Autism spectrum disorders (ASD) include autistic disorder, Asperger’s disorder and pervasive developmental disorder.
High Levels of IFN-Gamma, IL-4 and IL-5 in Mothers Bearing Autistic Children
- 13 September 2011
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Approximately 1 in 100 children is diagnosed with an autism spectrum disorder (ASD), and there are no clear biological markers for Mothers of children with ASD.
IL-27 and IFN-Gamma Cooperate to Induce Steroid Resistance in Asthma
- 27 September 2010
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The mechanisms predisposing to steroid insensitivity in asthma are poorly understood.
The Sympathetic Nervous System as a Regulator of Breast Cancer Metastasis
- 27 September 2010
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The effects of the neuroendocrine system and microenvironment on breast cancer metastasis remain largely unexplored.
Cold-Induced Sympathoexcitation and Adipokine Profiles in Humans
- 27 September 2010
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Adipose tissue, in tight interconnection with the sympathetic nervous system (SNS), has a key role in maintaining energy homeostasis, blood pressure control, immunoregulation, hemostasis, and atherosclerosis.
A Combination of Beta-Adrenergic Antagonist and Cyclooxygenase-2 Inhibitor Improves Survival Rates in Murine Models of Postoperative Metastasis
- 27 September 2010
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The surgical procedure, a common step in the treatment of most solid cancers, has long been suspected to facilitate the metastatic process, and numerous mechanisms have been implicated.
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